Sodium Hydroxide → HCID 11351381, compound

HRID 2180551Notes

Reaction equation

HRID 2180551 reaction equation
BrC1C=C2C(=CC=1OC)OC(C)(C)C=C2OS(C(F)(F)F)(=O)=O.ClC1C(OCC)=C(OC(=O)/C=C(\C)/C=C/C(/F)=C\C)C=C2C=1OC(C)(C)C=C2C(C)C.[Cl:55][C:56]1[C:57]([O:85][CH2:86][CH3:87])=[C:58](/[C:71](/[CH3:84])=[C:72](/[F:83])\[CH:73]=[CH:74]\[C:75](\[CH3:82])=[CH:76]\[C:77]([O:79]CC)=[O:78])[CH:59]=[C:60]2[C:65]=1[O:64][C:63]([CH3:67])([CH3:66])[CH:62]=[C:61]2[CH:68]([CH3:70])[CH3:69].[OH-].[Na+]>C(O)C.C1COCC1>[Cl:55][C:56]1[C:57]([O:85][CH2:86][CH3:87])=[C:58](/[C:71](/[CH3:84])=[C:72](/[F:83])\[CH:73]=[CH:74]\[C:75](\[CH3:82])=[CH:76]\[C:77]([OH:79])=[O:78])[CH:59]=[C:60]2[C:65]=1[O:64][C:63]([CH3:66])([CH3:67])[CH:62]=[C:61]2[CH:68]([CH3:69])[CH3:70]

Participants

7

Reactant 4

HCID 14798Sodium HydroxideHCID 20779605HCID 20779605, compoundHCID 87973012HCID 87973012, compoundHCID 131724862HCID 131724862, compound

Product 1

HCID 11351381HCID 11351381, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Following General Procedure G, a solution of ethyl 7L(8-chloro-4-isopropyl-7-ethoxy-2,2-dimethyl-2H-chromen-6-yl)-6-fluoro-3-methyl-octa-2E,4E,6E-trienoate (Compound 166, 874 mg, 1.95 mmol) in ethanol and THF was hydrolyzed with 1M NaOH to give rise to the title compound as a light yellow solid.

Sources & evidence

ORD record
ord-fd569fa241e243368abeb94a3bfeed46
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

Loading…