Potassium Carbonate → HCID 22218326, compound

HRID 2180564Notes

Reaction equation

HRID 2180564 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:16])([CH3:15])[CH2:7][CH:8]=[C:9]2[CH:12]([CH3:14])[CH3:13])=[CH:4][C:3]=1[OH:17].C(=O)([O-])[O-].[K+].[K+].I[CH2:25][CH2:26][CH3:27]>CC(C)=O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:15])([CH3:16])[CH2:7][CH:8]=[C:9]2[CH:12]([CH3:13])[CH3:14])=[CH:4][C:3]=1[O:17][CH2:25][CH2:26][CH3:27]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 22218215HCID 22218215, compound

Product 1

HCID 22218326HCID 22218326, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

As described in General Procedure D-1, 7-bromo-4,4-dimethyl-6-hydroxy-1-isopropyl-3,4-dihydronaphthalene (Compound A-30, U.S. Pat. No. 6,613,917, 0.100 g, 0.339 mmol), potassium carbonate (140 mg) and 1-iodopropane (0.331 mL, 3.39 mmol), were reacted in acetone (3 mL) to produce the title compound as a clear oil after purification by flash column chromatography (silica gel, 98:2 hexane/ethyl acetate).

Sources & evidence

ORD record
ord-3e69825b286c45a999e0dbaef63c26bc
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

Loading…