Potassium Carbonate → HCID 22491012, compound

HRID 2180565Notes

Reaction equation

HRID 2180565 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:17])([CH3:16])[CH2:7][CH:8]=[C:9]2[C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:4][C:3]=1[OH:18].C(=O)([O-])[O-].[K+].[K+].I[CH2:26][CH2:27][CH3:28]>CC(C)=O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:17])([CH3:16])[CH2:7][CH:8]=[C:9]2[C:12]([CH3:13])([CH3:15])[CH3:14])=[CH:4][C:3]=1[O:18][CH2:26][CH2:27][CH3:28]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 22218257HCID 22218257, compound

Product 1

HCID 22491012HCID 22491012, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

As described in General Procedure D-1, 7-bromo-4,4-dimethyl-6-hydroxy-1-tert-butyl-3,4-dihydronaphthalene (Compound A-31, U.S. Pat. No. 6,613,917, 070 g, 0.226 mmol), potassium carbonate (94 mg) and 1-iodopropane (0.220 mL, 2.26 mmol), were reacted in acetone (3 mL) to produce the title compound as a clear oil.

Sources & evidence

ORD record
ord-f7e3957fa20940f1937e05f2fa764e31
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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