Diisobutylaluminumhydride → HCID 22490980, compound

HRID 2180572Notes

Reaction equation

HRID 2180572 reaction equation
[H-].C([Al+]CC(C)C)C(C)C.[F:11]/[C:12](=[C:18](/[C:20]1[CH:29]=[C:28]2[C:23]([C:24]([CH3:34])([CH3:33])[CH2:25][CH:26]=[C:27]2[CH:30]([CH3:32])[CH3:31])=[CH:22][C:21]=1[O:35][CH2:36][CH3:37])\[CH3:19])/[C:13](OCC)=[O:14]>C1COCC1>[F:11]/[C:12](=[C:18](/[C:20]1[CH:29]=[C:28]2[C:23]([C:24]([CH3:34])([CH3:33])[CH2:25][CH:26]=[C:27]2[CH:30]([CH3:32])[CH3:31])=[CH:22][C:21]=1[O:35][CH2:36][CH3:37])\[CH3:19])/[CH2:13][OH:14]

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 86597841HCID 86597841, compound

Product 1

HCID 22490980HCID 22490980, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following General Procedure G-1, diisobutylaluminum hydride (1.0 M in hexanes, 2.2 mL, 2.2 mmol) and ethyl (2E)-2-fluoro-3-(4,4-dimethyl-6-ethoxy-1-isopropyl-3,4-dihydronaphthalen-7-yl)-2-butenoate (Compound A-43, 0.205 g, 0.55 mmol) in THF (6 mL) were reacted to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-5248750ad53546a2ba77052d589e886a
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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