Diisobutylaluminumhydride → HCID 22490882, compound

HRID 2180573Notes

Reaction equation

HRID 2180573 reaction equation
[F:1]/[C:2](=[C:8](/[C:10]1[CH:19]=[C:18]2[C:13]([C:14]([CH3:24])([CH3:23])[CH2:15][CH:16]=[C:17]2[CH:20]([CH3:22])[CH3:21])=[CH:12][C:11]=1[O:25][CH2:26][CH:27]1[CH2:29][CH2:28]1)\[CH3:9])/[C:3](OCC)=[O:4].[H-].C([Al+]CC(C)C)C(C)C>C1COCC1>[F:1]/[C:2](=[C:8](/[C:10]1[CH:19]=[C:18]2[C:13]([C:14]([CH3:24])([CH3:23])[CH2:15][CH:16]=[C:17]2[CH:20]([CH3:22])[CH3:21])=[CH:12][C:11]=1[O:25][CH2:26][CH:27]1[CH2:29][CH2:28]1)\[CH3:9])/[CH2:3][OH:4]

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 86597842HCID 86597842, compound

Product 1

HCID 22490882HCID 22490882, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

As described in General Procedure G-1, ethyl (2E)-2-fluoro-3-(4,4-dimethyl-6(cyclopropyl)methoxy-1-iso-propyl-3,4-dihydronaphthalen-7-yl)-2-butenoate (Compound A-45, 0.025 g, 0.062 mmol) and diisobutylaluminum hydride (1.0 M in hexanes, 0.50 mL, 0.50 mmol) were reacted in THF (0.5 mL) to produce the title compound as an oil.

Sources & evidence

ORD record
ord-dfe3eb6f575b4ea2879acdfa2b8ded8e
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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