Diisobutylaluminumhydride → HCID 22490808, compound

HRID 2180574Notes

Reaction equation

HRID 2180574 reaction equation
[F:1]/[C:2](=[C:8](/[C:10]1[CH:19]=[C:18]2[C:13]([C:14]([CH3:25])([CH3:24])[CH2:15][CH:16]=[C:17]2[C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:12][C:11]=1[O:26][CH2:27][CH3:28])\[CH3:9])/[C:3](OCC)=[O:4].[H-].C([Al+]CC(C)C)C(C)C>C1COCC1>[F:1]/[C:2](=[C:8](/[C:10]1[CH:19]=[C:18]2[C:13]([C:14]([CH3:25])([CH3:24])[CH2:15][CH:16]=[C:17]2[C:20]([CH3:22])([CH3:21])[CH3:23])=[CH:12][C:11]=1[O:26][CH2:27][CH3:28])\[CH3:9])/[CH2:3][OH:4]

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 86759713HCID 86759713, compound

Product 1

HCID 22490808HCID 22490808, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

As described in General Procedure G-1, ethyl (2E)-2-fluoro-3-(4,4 dimethyl-6-ethoxy-1-tert-butyl-3,4-dihydronaphthalen-7-yl)-2-butenoate (Compound A-46, 0.037 g, 0.095 mmol) and diisobutylaluminum hydride (1.0 M in hexanes, 0.76 mL, 0.76 mmol) were reacted in THF (0.75 mL) to produce the title compound as an oil.

Sources & evidence

ORD record
ord-b51f1fd71ff0455b936ca2f8472b1c67
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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