Methyl morpholine oxide → HCID 86597845, compound

HRID 2180577Notes

Reaction equation

HRID 2180577 reaction equation
[CH2:1]([O:3][C:4]1[C:5](/[C:16](/[CH2:21][CH3:22])=[C:17](/[F:20])\[CH2:18][OH:19])=[CH:6][C:7]2[CH:8]=[CH:9][CH2:10][C:11]([CH3:15])([CH3:14])[C:12]=2[CH:13]=1)[CH3:2].C[N+]1([O-])CCOCC1>>[CH2:1]([O:3][C:4]1[C:5](/[C:16](/[CH2:21][CH3:22])=[C:17](/[F:20])\[CH:18]=[O:19])=[CH:6][C:7]2[CH:8]=[CH:9][CH2:10][C:11]([CH3:14])([CH3:15])[C:12]=2[CH:13]=1)[CH3:2]

Participants

3

Reactant 2

HCID 82029Methyl morpholine oxideHCID 69731067HCID 69731067, compound

Product 1

HCID 86597845HCID 86597845, compound

Procedure

Following General Procedure H-1, (2E)-3-(3-ethoxy-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-2-fluoro-pent-2-en-1-ol (Compound A-50, 35 mg, 0.12 mmol) and 4-methylmorpholine N-oxide (27 mg, 0.23 nmol) were reacted to give the title compound as a yellow solid after purification by flash chromatography (silica gel, 10% ethyl acetate in hexanes).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f73cde027d424cce80f67ad1455a18cd
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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