反应详情

温度

150 °C

4-Fluoroacetophenone (969 μl, 8.00 mmol) was added to dry N,N-dimethylacetamide (12 ml) solution of 6-benzyloxy-2-naphthol (500 mg, 2.00 mmol) and potassium carbonate (553 mg, 4.00 mmol) in nitrogen atmosphere and stirred at 150° C. for 5 hours. After completing the reaction, 10% citric acid was added to the reaction liquid, extracted with methylene chloride, washed with water, dried with magnesium sulfate and concentrated. The obtained residue was purified by silica gel chromatography to obtain the subject compound (707 mg, 1.92 mmol). The result of 1H-NMR was consistent with the above structure.

1. additionwas added to the reaction liquid
2. extractionextracted with methylene chloride
3. washwashed with water
4. dry with materialdried with magnesium sulfate
5. concentrationconcentrated
6. customThe obtained residue was purified by silica gel chromatography