L-Methionine → HCID 69796973, compound

HRID 2181282Notes

Reaction equation

HRID 2181282 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][C:7]2(O)[CH:13]([CH2:14][N:15]([CH3:17])[CH3:16])[CH2:12][CH2:11][O:10][C:9]3[CH:18]=[CH:19][CH:20]=[CH:21][C:8]2=3)=[CH:4][CH:3]=1.CS(O)(=O)=O.N[C@H](C(O)=O)CCSC>>[ClH:1].[Cl:1][C:2]1[CH:24]=[CH:23][C:5](/[CH:6]=[C:7]2\[C:8]3[CH:21]=[CH:20][CH:19]=[CH:18][C:9]=3[O:10][CH2:11][CH2:12][CH:13]\2[CH2:14][N:15]([CH3:17])[CH3:16])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6137L-MethionineHCID 6395Methanesulfonic AcidHCID 22485738HCID 22485738, compound

Product 1

HCID 69796973HCID 69796973, compound

Procedure

7.27 g (4RS,5RS)-5-(4-chlorobenzyl)-4-dimethylaminomethyl-2,3,4,5-tetrahydrobenzo[b]oxepin-5-ol were reacted with 43 ml methanesulfonic acid and 4.81 g methionine analogously to the procedure described in example 6. After similarly analogous working up, separation of the product and salt formation, the title compounds were obtained in the form of white crystals.

Workup

  1. customseparation of the product and salt formation

Sources & evidence

ORD record
ord-466a55aa1bd647969575c0139c8a279c
Source dataset
uspto-grants-2005_05
Patent number
US06890952B2

Reaction notes

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