Hydrochloric Acid → HCID 12115354, compound

HRID 2181714Notes

Reaction equation

HRID 2181714 reaction equation
[Cl:1][C:2]1[C:11]([O:12][CH2:13][C:14]([N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:15])=[C:10]([S:21]([CH2:24][CH3:25])(=[O:23])=[O:22])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl>C1COCC1.O>[Cl:1][C:2]1[C:11]([O:12][CH2:13][C:14]([N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:15])=[C:10]([S:21]([CH2:24][CH3:25])(=[O:23])=[O:22])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12115353HCID 12115353, compound

Product 1

HCID 12115354HCID 12115354, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

0.500 g of methyl 2-chloro-3-(pyrrolidinocarbonylmethoxy)-4-ethylsulfonylbenzoate were dissolved in 20 ml of THF and 20 ml of water, 0.056 g of NaOH was added and the mixture was stirred at RT for 12 hours. The mixture was admixed with 6 N HCl and extracted with CH2Cl2. Drying of the organic phase over Na2SO4 gave 2-chloro-3-(pyrrolidinocarbonylmethoxy)-4-ethylsulfonylbenzoic acid as a viscous colorless oil.

Workup

  1. extractionextracted with CH2Cl2
  2. dry with materialDrying of the organic phase over Na2SO4

Sources & evidence

ORD record
ord-ab00247b80794707bc27bd333420d5ba
Source dataset
uspto-grants-2005_05
Patent number
US06894070B2

Reaction notes

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