Potassium Carbonate → HCID 22482348, compound

HRID 2181887Notes

Reaction equation

HRID 2181887 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9]([NH:12][CH:13]([C:15]2[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=2[C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=2F)[CH3:14])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:28][C:25]1[CH:26]=[CH:27][C:22]2[C:16]3[C:15]([CH:13]([CH3:14])[N:12]([S:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=4)(=[O:11])=[O:10])[C:23]=2[CH:24]=1)=[CH:20][C:19]([F:21])=[CH:18][CH:17]=3

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22482397HCID 22482397, compound

Product 1

HCID 22482348HCID 22482348, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A stirred suspension of 3-methoxy-N-[1-(2′,4,4′-trifluoro-1,1′-biphenyl-2-yl)ethyl]benzenesulfonamide (0.88 g, 2.1 mmol) and potassium carbonate (0.58 g, 4.2 mmol) in N,N-dimethylformamide (5 mL) was heated for twelve hours at 100° C. The reaction mixture was cooled and poured into distilled water. After stirring overnight at room temperature, a precipitate was filtered and dried under high vacuum. The title compound (0.81 g, 2.0 mmol, 96%) was obtained as a colorless, fine, crystalline powder, m.p. 147-149° C.;

Workup

  1. temperatureThe reaction mixture was cooled
  2. additionpoured
  3. distillationinto distilled water
  4. filtrationa precipitate was filtered
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-37109312c8a642a9aa0da9a9eb1a0cf5
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Reaction notes

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