Potassium Carbonate → HCID 22482368, compound

HRID 2181889Notes

Reaction equation

HRID 2181889 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[S:11]([NH:14][CH:15]([C:17]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=1[C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=1F)[CH3:16])(=[O:13])=[O:12].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[S:11]([N:14]1[CH:15]([CH3:16])[C:17]2[C:18](=[CH:19][CH:20]=[C:21]([F:23])[CH:22]=2)[C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]1=2)(=[O:13])=[O:12]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22482293HCID 22482293, compound

Product 1

HCID 22482368HCID 22482368, compoundYield 91.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A stirred suspension of 2,4-dimethoxy-N-[1-(2′,4,4′-trifluoro-1,1′-biphenyl-2-yl)ethyl]benzenesulfonamide (0.86 g, 1.91 mmol) and potassium carbonate (0.53 g, 3.82 mmol) in N,N-dimethylformamide (5 mL) was heated for twelve hours at 100° C. The reaction mixture was cooled and poured into distilled water. After stirring overnight at room temperature, a precipitate was filtered and dried under high vacuum. The title compound (0.75 g, 1.74 mmol, 91%) was obtained as a colorless, fine, crystalline powder, m.p. 112-115° C.;

Workup

  1. temperatureThe reaction mixture was cooled
  2. additionpoured
  3. distillationinto distilled water
  4. filtrationa precipitate was filtered
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-84c30dde206e424a92a171f287e5059d
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Reaction notes

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