Ammonium Acetate → 1-(2',5'-Difluoro-1,1'-biphenyl-2-yl)ethylamine

HRID 2181900Notes

Reaction equation

HRID 2181900 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15](=O)[CH3:16].C([O-])(=O)C.[NH4+].C([BH3-])#[N:24].[Na+]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH:15]([NH2:24])[CH3:16]

Participants

5

Reactant 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 224823961-(2',5'-Difluoro-1,1'-biphenyl-2-yl)ethanone

Product 1

HCID 224822831-(2',5'-Difluoro-1,1'-biphenyl-2-yl)ethylamine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared from 1-(2′,5′-difluoro-1,1′-biphenyl-2-yl)ethanone (2.0 g, 8.6 mmol), anhydrous methanol (100 mL), ammonium acetate (13.3 g, 172 mmol), and sodium cyanoborohydride (1.08 g, 17.2 mmol) according to the procedure and in the same manner as described in Example 105, step b;

Sources & evidence

ORD record
ord-9465f3c683de4a22b3818456430bdbc4
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Reaction notes

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