Triethylamine → HCID 22482374, compound

HRID 2181932Notes

Reaction equation

HRID 2181932 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[S:11](Cl)(=[O:13])=[O:12].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH:28]([NH2:30])[CH3:29])=[C:18]([F:31])[CH:17]=1.C(N(CC)CC)C>>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH:28]([NH:30][S:11]([C:4]2[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[CH:8][C:3]=2[O:2][CH3:1])(=[O:13])=[O:12])[CH3:29])=[C:18]([F:31])[CH:17]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 27346262,4-Dimethoxybenzenesulfonyl chlorideHCID 224823611-(4'-Chloro-2'-fluoro-biphenyl-2-yl)-ethylamine

Product 1

HCID 22482374HCID 22482374, compound

Procedure

The title compound was prepared from 2,4-dimethoxybenzenesulfonyl chloride (379 mg, 1.6 mmol), 1-(4′-chloro-2′-fluoro-1,1′-biphenyl-2-yl)ethylamine (400 mg, 1.6 mmol), and triethylamine (246 μL, 1.7 mmol) according to the procedure and in the same manner as described in Example 105, step c resulting in the isolation of 480 mg (67%) of a white solid;

Sources & evidence

ORD record
ord-ee093dd17c7f4366b940b04a008c5b02
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Reaction notes

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