HRID21820

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)[C@H](Cc1ccc(N(CCCl)CCCl)cc1)NC(=O)OC(C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC

HCID10772367

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)[C@@H](N)Cc1ccc(N(CCCl)CCCl)cc1)OC(=O)CCCCCCCCCCCCCCCCC

HCID9811548

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

PROCEDURE

实验过程

A solution of 5 mmol of the product obtained in Example 1 in 25 ml of hydrogen chloride-saturated dioxane is stirred for 20 minutes at 20° C. The whole mixture is concentrated under vacuum and the residue is washed with pentane, to give the expected product in hydrochloride form.

WORKUP

后处理

concentrationThe whole mixture is concentrated under vacuum
washthe residue is washed with pentane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-82bd3a41a9f147679decbb201340163b
来源数据集: uspto-grants-1995_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05424464
来源说明: uspto-grants-1995_06

反应 SMILES

[C:1]([O:20][CH2:21][CH:22]([CH2:43][O:44][C:45](=[O:69])[C@H:46]([CH2:55][C:56]1[CH:61]=[CH:60][C:59]([N:62]([CH2:66][CH2:67][Cl:68])[CH2:63][CH2:64][Cl:65])=[CH:58][CH:57]=1)[NH:47]C(OC(C)(C)C)=O)[O:23][C:24](=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>Cl>[C:1]([O:20][CH2:21][CH:22]([CH2:43][O:44][C:45](=[O:69])[C@H:46]([CH2:55][C:56]1[CH:57]=[CH:58][C:59]([N:62]([CH2:66][CH2:67][Cl:68])[CH2:63][CH2:64][Cl:65])=[CH:60][CH:61]=1)[NH2:47])[O:23][C:24](=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]