HCID 10772367, compound → HCID 9811548, compound

HRID 21820Notes

Reaction equation

HRID 21820 reaction equation
[C:1]([O:20][CH2:21][CH:22]([CH2:43][O:44][C:45](=[O:69])[C@H:46]([CH2:55][C:56]1[CH:61]=[CH:60][C:59]([N:62]([CH2:66][CH2:67][Cl:68])[CH2:63][CH2:64][Cl:65])=[CH:58][CH:57]=1)[NH:47]C(OC(C)(C)C)=O)[O:23][C:24](=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>Cl>[C:1]([O:20][CH2:21][CH:22]([CH2:43][O:44][C:45](=[O:69])[C@H:46]([CH2:55][C:56]1[CH:57]=[CH:58][C:59]([N:62]([CH2:66][CH2:67][Cl:68])[CH2:63][CH2:64][Cl:65])=[CH:60][CH:61]=1)[NH2:47])[O:23][C:24](=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 1

HCID 10772367HCID 10772367, compound

Product 1

HCID 9811548HCID 9811548, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 5 mmol of the product obtained in Example 1 in 25 ml of hydrogen chloride-saturated dioxane is stirred for 20 minutes at 20° C. The whole mixture is concentrated under vacuum and the residue is washed with pentane, to give the expected product in hydrochloride form.

Workup

  1. concentrationThe whole mixture is concentrated under vacuum
  2. washthe residue is washed with pentane

Sources & evidence

ORD record
ord-82bd3a41a9f147679decbb201340163b
Source dataset
uspto-grants-1995_06
Patent number
US05424464

Reaction notes

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