HCID 22482760, compound → HCID 12069438, compound

HRID 2182064Notes

Reaction equation

HRID 2182064 reaction equation
Cl.[C:2]([C:5]1[CH2:10][NH:9][CH2:8][CH2:7][CH:6]=1)(=[O:4])[NH2:3]>C(=O)([O-])O.[Na+]>[C:2]([C:5]1[CH2:10][NH:9][CH2:8][CH2:7][CH:6]=1)(=[O:4])[NH2:3]

Participants

3

Reactant 1

HCID 22482760HCID 22482760, compound

Product 1

HCID 12069438HCID 12069438, compound

Reagents, catalysts & solvents 1

HCID 516892Sodium BicarbonateSolvent

Procedure

5-carbamoyl-1,2,3,6-tetrahydropyridine hydrochloride was dissolved in a saturated aqueous solution of sodium hydrogen carbonate, followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate. After the desiccant was filtered off, the filtrate was concentrated under reduced pressure to yield crystals of free 5-carbamoyl-1,2,3,6-tetrahydropyridine.

Workup

  1. extractionfollowed by extraction with chloroform
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. filtrationAfter the desiccant was filtered off
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4e7c079827854e52b37e0f29ff0eb8f4
Source dataset
uspto-grants-2005_05
Patent number
US06894168B2

Reaction notes

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