Hydrochloric Acid → HCID 178503093, compound

HRID 2182352Notes

Reaction equation

HRID 2182352 reaction equation
[CH3:1][C:2]1[C:25]([CH3:26])=[CH:24][C:5]2[N:6](COCC[Si](C)(C)C)[C:7]([C:9]3[CH:13]=[C:12]([S:14][CH3:15])[NH:11][N:10]=3)=[N:8][C:4]=2[CH:3]=1.Cl.C(=O)(O)[O-].[Na+]>C(O)C>[CH3:26][C:25]1[C:2]([CH3:1])=[CH:3][C:4]2[NH:8][C:7]([C:9]3[CH:13]=[C:12]([S:14][CH3:15])[NH:11][N:10]=3)=[N:6][C:5]=2[CH:24]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 178503092HCID 178503092, compound

Product 1

HCID 178503093HCID 178503093, compoundYield 63.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5,6-dimethyl-2-(5-methylsulfanyl-1H-pyrazol-3-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazole [90 mg, Reference Example 1 (a)], hydrochloric acid (2 ml, 4N) and ethanol (4 mL) mixture was adjusted to 7 by addition of saturated sodium bicarbonate solution. The resulting solid was filtered, then washed with water and then dried in a vacuum oven to give 5,6-dimethyl-2-(5-methylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole (38 mg). LC-MS (METHOD A): RT =2.22 minutes; 259 (M+H)+. (b) 6-Chloro-5-methyl-2-(5-methylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole

Workup

  1. filtrationThe resulting solid was filtered
  2. washwashed with water
  3. customdried in a vacuum oven

Sources & evidence

ORD record
ord-3865f94cfe144b57a64f96224ca6e30e
Source dataset
uspto-grants-2005_05
Patent number
US06897208B2

Reaction notes

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