Semicarbazide hydrochloride → Ethyl pyruvate semicarbazide

HRID 2182428Notes

Reaction equation

HRID 2182428 reaction equation
Cl.[NH2:2][NH:3][C:4]([NH2:6])=[O:5].C([O-])(=O)C.[Na+].[C:12]([O:17][CH2:18][CH3:19])(=[O:16])[C:13]([CH3:15])=[O:14]>O>[NH2:2][NH:3][C:4]([NH2:6])=[O:5].[C:12]([O:17][CH2:18][CH3:19])(=[O:16])[C:13]([CH3:15])=[O:14]

Participants

5

Reactant 3

HCID 11236Semicarbazide hydrochlorideHCID 12041Ethyl pyruvateHCID 517045Sodium Acetate

Product 1

HCID 22477923Ethyl pyruvate semicarbazide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A stirred solution of semicarbazide hydrochloride (11.1 g) and sodium acetate (8.2 g) in water (250 ml) was treated with ethyl pyruvate (10.9 ml) in one portion. The resulting white precipitate was collected by filtration to yield ethyl pyruvate semicarbazide (16.59 g) as a white powder. LC-MS (Method J): RT=2.38 minutes, 174.31 (M+H)+, 172.32 (M−H)−.

Workup

  1. filtrationThe resulting white precipitate was collected by filtration

Sources & evidence

ORD record
ord-10ff88b54fb44e3e837b0a0ecc9e3b1b
Source dataset
uspto-grants-2005_05
Patent number
US06897208B2

Reaction notes

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