Isopropyl iodide → HCID 22479275, compound

HRID 2182629Notes

Reaction equation

HRID 2182629 reaction equation
I[CH:2]([CH3:4])[CH3:3].[OH:5][C:6]1[CH:30]=[CH:29][C:9]([CH2:10][C:11]23[CH2:18][CH2:17][CH2:16][N:15]2[C:14](=[O:19])[N:13]([C:20]2[CH:25]=[C:24]([Cl:26])[N:23]=[C:22]([Cl:27])[CH:21]=2)[C:12]3=[O:28])=[CH:8][CH:7]=1>CN(C=O)C.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>[CH:2]([O:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:10][C:11]23[CH2:18][CH2:17][CH2:16][N:15]2[C:14](=[O:19])[N:13]([C:20]2[CH:21]=[C:22]([Cl:27])[N:23]=[C:24]([Cl:26])[CH:25]=2)[C:12]3=[O:28])=[CH:29][CH:30]=1)([CH3:4])[CH3:3]

Participants

5

Reactant 2

HCID 6362Isopropyl iodideHCID 22479133HCID 22479133, compound

Product 1

HCID 22479275HCID 22479275, compound

Reagents, catalysts & solvents 2

HCID 311Citric AcidSolventHCID 6228DimethylformamideSolvent

Procedure

2-Iodopropane (0.5 ml) was added to a suspension of Example 196 (0.17 g) and CS2CO3 (0.28 g) in DMF (3 mL) and the mixture was stirred for 4 hours. The mixture was diluted with citric acid and the solution was extracted with EtOAc. EtOAc layer was washed with water and brine, dried and evaporated. The residue was purified via HPLC to yield the titled compound (0.13 g). MS m/z 435(MH+).

Workup

  1. extractionthe solution was extracted with EtOAc
  2. washEtOAc layer was washed with water and brine
  3. customdried
  4. customevaporated
  5. customThe residue was purified via HPLC

Sources & evidence

ORD record
ord-65128c4a6bf8466c81a6c723692e3534
Source dataset
uspto-grants-2005_05
Patent number
US06897225B1

Reaction notes

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