HCID 10215510, compound → Hydrochloric Acid

HRID 2182822Notes

Reaction equation

HRID 2182822 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[N:11]([CH3:25])[C:12]([CH3:24])=[C:13]([CH:16]([OH:23])[C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)[C:14]=2[CH3:15])=[O:9])=[CH:4][CH:3]=1.[Cl:26]C1C=CC(C(C2N(C)C=C(C(C3[NH2+]CN(C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)C=3)=O)C=2)=O)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[N:11]([CH3:25])[C:12]([CH3:24])=[C:13]([CH:16]([OH:23])[C:17]3[CH:18]=[CH:19][N:20]=[CH:21][CH:22]=3)[C:14]=2[CH3:15])=[O:9])=[CH:4][CH:3]=1.[ClH:26]

Participants

4

Reactant 2

HCID 10215510HCID 10215510, compoundHCID 86589673HCID 86589673, compound

Product 2

HCID 313Hydrochloric AcidHCID 10215510HCID 10215510, compound

Procedure

By the method of Procedure 7 substituting (4-chlorophenyl)-[4-(hydroxypyridin-4-yl-methyl )-1,3,5-trimethyl-1H-pyrrol-2-yl]-methanone for 5-[[2-(4-chlorobenzoyl)-1-methyl-1H-pyrrol-4-yl]carbonyl]-3-(triphenylmethyl)-1H-imidazolium the title compound was prepared. Treatment with ethereal HCl gave 35% yield of the hydrochloride salt. Mp. 174-176° C. ES-MS m/z=353 (M++H). 1HNMR (CDCl3) δ 8.9 (ar, 2H); 8 (ar, 2H); 7.7 (ar, 2H); 7.5 (ar, 2H); 3.75 (s, 3H); 2.3 (s, 3H); 2.65 (s, 3H).

Sources & evidence

ORD record
ord-735f22f4ab0d497f823ce7bc87874f0a
Source dataset
uspto-grants-2005_05
Patent number
US06897319B2

Reaction notes

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