Hydrochloric Acid → 2-Imino-1-methylimidazolidin-4-one hydrochloride

HRID 2182829Notes

Reaction equation

HRID 2182829 reaction equation
O.[O:2]=[C:3]([CH2:5][N:6]([C:8](=[NH:10])[NH2:9])[CH3:7])O.[ClH:11]>>[CH3:7][N:6]1[C:8]([NH2:10])=[N:9][C:3](=[O:2])[CH2:5]1.[ClH:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 80116Creatine Monohydrate

Product 1

HCID 879722-Imino-1-methylimidazolidin-4-one hydrochloride

Procedure

Shortening the reaction time from 20 hours to 10-12 hours resulted in a decrease in the conversion of creatine monohydrate to CEE HCl to about 76 to 83%. Increasing the reaction time to greater than 20 hours resulted in no significant increase in the conversion of creatine monohydrate to CEE HCl. Such longer reaction times, however, did result in the increased formation of the undesirable product creatinine HCl.

Workup

  1. temperatureIncreasing the reaction time to greater than 20 hours
  2. customresulted in
  3. customSuch longer reaction times

Sources & evidence

ORD record
ord-b174ea643a3b4aaa94c5f886100282ec
Source dataset
uspto-grants-2005_05
Patent number
US06897334B2

Reaction notes

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