Trifluoroacetic acid → HCID 131724902, compound

HRID 2183084Notes

Reaction equation

HRID 2183084 reaction equation
C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O.[NH2:16][C:17]1[S:18][CH:19]=[C:20]([C:22](=[N:52][O:53][C:54](C(O)=O)(C)C)[C:23]([NH:25][CH:26]2[C:50](=[O:51])[N:28]3[C:29]([C:47]([OH:49])=[O:48])=[C:30]([CH:33]=[CH:34][C:35]4[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][C:36]=4[N+]([O-])=O)[CH2:31][S:32][C@H:27]23)=[O:24])[N:21]=1>>[NH2:16][C:17]1[S:18][CH:19]=[C:20]([C:22](=[N:52][O:53][CH3:54])[C:23]([NH:25][CH:26]2[C:50](=[O:51])[N:28]3[C:29]([C:47]([OH:49])=[O:48])=[C:30]([CH:33]=[CH:34][C:35]4[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=4)[CH2:31][S:32][C@H:27]23)=[O:24])[N:21]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 131724899HCID 131724899, compound

Product 1

HCID 131724902HCID 131724902, compoundYield 70%

Procedure

This compound (210 mg, 0.22 mmol), anisole (0.5 ml, 4.5 mmol) and trifluoro acetic acid (2.5 ml, 33.8 mmol) were used to conduct the procedure similar to that shown in (2) of Example 1 to obtain 100 mg (yield: 70%) of the titled compound as yellow powder.

Sources & evidence

ORD record
ord-7d23e50ab72f4279875656de6a538260
Source dataset
uspto-grants-2005_05
Patent number
US06897304B2

Reaction notes

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