Trifluoroacetic acid → HCID 131724905, compound

HRID 2183086Notes

Reaction equation

C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O.[NH2:16][C:17]1[S:18][CH:19]=[C:20]([C:22](=[N:52][O:53][C:54]([C:57]([OH:59])=[O:58])(C)C)[C:23]([NH:25][CH:26]2[C:50](=[O:51])[N:28]3[C:29]([C:47]([OH:49])=[O:48])=[C:30]([CH:33]=[CH:34][C:35]4[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][C:36]=4[N+:44]([O-:46])=[O:45])[CH2:31][S:32][C@H:27]23)=[O:24])[N:21]=1>>[NH2:16][C:17]1[S:18][CH:19]=[C:20]([C:22](=[N:52][O:53][CH2:54][C:57]([OH:59])=[O:58])[C:23]([NH:25][CH:26]2[C:50](=[O:51])[N:28]3[C:29]([C:47]([OH:49])=[O:48])=[C:30]([CH:33]=[CH:34][C:35]4[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][C:36]=4[N+:44]([O-:46])=[O:45])[CH2:31][S:32][C@H:27]23)=[O:24])[N:21]=1

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 7519Anisole

HCID 131724899HCID 131724899, compound

Product 1

HCID 131724905HCID 131724905, compoundYield 73%

Procedure

This compound (238 mg, 0.22 mmol), anisole (0.5 ml, 4.5 mmol) and trifluoro acetic acid (2.5 ml, 33.8 mmol) were used to conduct the procedure similar to that shown in (2) of Example 1 to obtain 120 mg (yield: 73%) of the titled compound as yellow powder.

Sources & evidence

ORD record: ord-9eebf7264a5d400ab6177493f555b461
Source dataset: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06897304B2

Reaction notes

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