反应详情

1-Amino-1H-pyrrole-2-carboxamide (91 mg, 0.724 mmol) was dissolved in THF (3 mL), then 1-cyclopentene-1,2-dicarboxylic anhydride (100 mg, 0.724 mmol) was added. The reaction was stirred at rt for 30 min, then 0.5 M HCl (10 mL) was added. The precipitated product was filtered, rinsing with more 0.5 M HCl. The solids were dried to give 19A (177 mg, 92%). 19A had an analytical HPLC retention time=1.597 min (Phenomenex Luna 4.6×50 mm, 10-90% aqueous MeOH over 5 min containing 0.1% TFA) and a LC/MS M++1=264.

1. filtrationThe precipitated product was filtered
2. washrinsing with more 0.5 M HCl
3. customThe solids were dried