反应详情

2 g (9.28 mmol) of epoxide 2h in solution in 5 cm3 of anhydrous DMF were heated to reflux for 3 h. The solution was acidified (pH=1) with 3N HCl, extracted with ether (4×25 cm3), dried over MgSO4, filtered and evaporated down. The crude product obtained was purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95). 1.18 g of phenol 4e were obtained (macrobore GC purity>96%). The yield of compound 4e was 89%.

1. temperatureto reflux for 3 h
2. extractionextracted with ether (4×25 cm3)
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. customevaporated down
6. customThe crude product obtained
7. customwas purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95)