Diisobutylaluminum hydride → 6-(Hydroxymethyl)-5-methyl-4-[(4-phenoxyphenyl)amino]pyrrolo[1,2-b]pyridazine-3-carbonitrile

Temperature

-78 °C

To a solution of compound 3A (41 mg, 0.10 mmol) in THF (2 mL) at −78° C. was added DIBAL-H (1.5 M in toluene, 0.13 mL, 0.20 mmol). The reaction mixture was stirred for 6 h at −78° C., warmed to 0° C. and stirred for an additional 2 h. The reaction mixture was quenched by the addition of methanol (3 mL) and sat. aq. Na2CO3 (3 mL) and then poured onto dichloromethane (20 mL). The layers were separated, the aqueous phase was extracted with dichloromethane (2×15 mL), and the combined organic extracts were dried over MgSO4, filtered, and concentrated in vacuo. Purification via preparative HPLC (YMC S5 ODS 20×100 mm, eluting with 30-100% aqueous methanol over 15 min containing 0.1% TFA, 20 mL/min) afforded 33 mg (90% yield) of compound 3B as a yellow solid. HPLC: 100% at 3.98 min (retention time) (YMC S5 ODS column, 4.6×50 mm, eluting with 10-90% aqueous methanol over 4 min containing 0.2% phosphoric acid, 4 mL/min, monitoring at 220 nm). MS (ES): m/z 371.19 [M+H]+.

1. temperaturewarmed to 0° C.
2. stirringstirred for an additional 2 h
3. customThe reaction mixture was quenched by the addition of methanol (3 mL) and sat. aq. Na2CO3 (3 mL)
4. additionpoured onto dichloromethane (20 mL)
5. customThe layers were separated
6. extractionthe aqueous phase was extracted with dichloromethane (2×15 mL)
7. dry with materialthe combined organic extracts were dried over MgSO4
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. customPurification
11. washvia preparative HPLC (YMC S5 ODS 20×100 mm, eluting with 30-100% aqueous methanol over 15 min containing 0.1% TFA, 20 mL/min)

ORD record

ord-613c0038814c44daac85bb9ecefc1cbb

Source dataset

uspto-grants-2005_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06900208B2