Hydrochloric Acid → 1-(4-Chlorobenzo[b]thien-2-yl)-1-propanone

HRID 2183616Notes

Reaction equation

HRID 2183616 reaction equation
[CH2:1]([Mg]Br)[CH3:2].[Cl:5][C:6]1[C:14]2[CH:13]=[C:12]([C:15](N(OC)C)=[O:16])[S:11][C:10]=2[CH:9]=[CH:8][CH:7]=1.O.Cl>O1CCCC1>[Cl:5][C:6]1[C:14]2[CH:13]=[C:12]([C:15](=[O:16])[CH2:1][CH3:2])[S:11][C:10]=2[CH:9]=[CH:8][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 224738924-chloro-N-methoxy-N-methylbenzo[b]thiophene-2-carboxamideHCID 178418443HCID 178418443, compound2×

Product 1

HCID 224738541-(4-Chlorobenzo[b]thien-2-yl)-1-propanone

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethylmagnesium bromide (1M solution in tetrahydrofuran; 17.2 ml) was added under nitrogen to a stirred solution of 4-chloro-N-methoxy-N-methylbenzo[b]thiophene-2-carboxamide (4 g; prepared in a manner similar to that described in Example 18) in tetrahydrofuran (120 ml) then the mixture was allowed to stand at ambient temperature for 30 minutes, heated under reflux for 30 minutes and allowed to stand at ambient temperature for 30 minutes. Further ethylmagnesium bromide (1M solution in tetrahydrofuran; 7.0 ml) was added and the mixture was allowed to stand at ambient temperature for 2 hours. Water (200 ml) and 5M hydrochloric acid (15 ml) were added, and the product was extracted into dichloromethane (2×90 ml). The combined extracts were dried (MgSO4) and the solvents were removed in vacuo. The residue was purified by column chromatography over silica using dichloromethane as eluant. Appropriate fractions were combined and the solvents removed in vacuo to leave 1-(4-chlorobenzo[b]thiophen-2-yl)propan-1-one (1.88 g) as a pale yellow solid, m.p. 96-98° C.

Workup

  1. customprepared in a manner similar to
  2. temperatureheated
  3. temperatureunder reflux for 30 minutes
  4. waitto stand at ambient temperature for 30 minutes
  5. waitto stand at ambient temperature for 2 hours
  6. extractionthe product was extracted into dichloromethane (2×90 ml)
  7. dry with materialThe combined extracts were dried (MgSO4)
  8. customthe solvents were removed in vacuo
  9. customThe residue was purified by column chromatography over silica
  10. customthe solvents removed in vacuo

Sources & evidence

ORD record
ord-0aaab9e0289b4dac8374d955fd4f678b
Source dataset
uspto-grants-2005_05
Patent number
US06900216B2

Reaction notes

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