反应详情

(R)-tert-butyl 3-((R)-(3-chlorophenyl)(cyanomethoxy)methyl)piperidine-1-carboxylate (36.8 g, 0.10 mol) was dissolved in anhydrous THF (350 mL), and the solution was heated under reflux under a nitrogen atmosphere. A solution of BH3.Me2S (30 mL, 0.30 mol) in THF was added drop wise, and stirring was continued under reflux overnight. The resulting solution was cooled to room temperature. The reaction was quenched by careful, drop wise addition of MeOH until bubbling ceased. After evaporation of the solution, the crude product was obtained (70 g), which was used for the next step without purification.

1. temperaturethe solution was heated
2. temperatureunder reflux under a nitrogen atmosphere
3. temperatureunder reflux overnight
4. customThe reaction was quenched by careful,
5. additionaddition of MeOH
6. customuntil bubbling
7. customAfter evaporation of the solution