4-Chloro-2,5-difluorobenzonitrile → [3-(5-Chloro-2-cyano-4-fluorophenoxy)pentyl]methylcarbamic acid, 1,1-dimethylethyl ester

HRID 2183847Notes

Reaction equation

HRID 2183847 reaction equation
[OH:1][CH:2]([CH2:14][CH3:15])[CH2:3][CH2:4][N:5]([CH3:13])[C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9].[Cl:16][C:17]1[C:24]([F:25])=[CH:23][C:20]([C:21]#[N:22])=[C:19](F)[CH:18]=1>CN(C)C=O>[Cl:16][C:17]1[C:24]([F:25])=[CH:23][C:20]([C:21]#[N:22])=[C:19]([CH:18]=1)[O:1][CH:2]([CH2:14][CH3:15])[CH2:3][CH2:4][N:5]([CH3:13])[C:6](=[O:12])[O:7][C:8]([CH3:10])([CH3:11])[CH3:9]

Participants

4

Reactant 2

HCID 112753024-Chloro-2,5-difluorobenzonitrileHCID 857904251,1-Dimethylethyl (3-hydroxypentyl)methylcarbamate

Product 1

HCID 91069775[3-(5-Chloro-2-cyano-4-fluorophenoxy)pentyl]methylcarbamic acid, 1,1-dimethylethyl ester

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The subtitle compound was prepared according to the method of Example 3 step (b) using (3-hydroxypentyl)methylcarbamic acid, 1,1-dimethylethyl ester and 4-chloro-2,5-difluorobenzonitrile in N,N-dimethylformamide.

Sources & evidence

ORD record
ord-786396e702c94e1e93c4348ce895536a
Source dataset
uspto-grants-2005_05
Patent number
US06900243B2

Reaction notes

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