反应详情

温度

80 °C

N-phenylglycine ethyl ester (781 mg, 4.3 mmol), 4-chlorobenzyl chloride (690 mg, 4.3 mmol) and sodium iodide (64 mg) were dissolved in toluene (7 mL) under argon. The reaction was heated in a graphite bath at 80° C. for 24 h. After cooling to room temperature, the reaction was diluted with ethyl acetate and washed with 1M HCl followed by brine. The solution was dried over MgSO4, filtered, and concentrated in vacuo. Purification of the resultant oil by flash chromatography (10:1 hexanes/EtOAc) afforded the title compound as a green oil (669 mg, 51%). MS (ES+) m/z 304 (MH+).

1. temperatureAfter cooling to room temperature
2. washwashed with 1M HCl
3. dry with materialThe solution was dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customPurification of the resultant oil by flash chromatography (10:1 hexanes/EtOAc)