Water → HCID 22476088, compound

HRID 2184234Notes

Reaction equation

HRID 2184234 reaction equation
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[O:11][CH3:12].[C:13]1(=[O:23])[NH:17][C:16](=[O:18])[C:15]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:14]12.[K].O>CN(C=O)C>[C:13]1(=[O:23])[N:17]([CH2:2][C:3]2[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=2[O:11][CH3:12])[C:16](=[O:18])[C:15]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:14]12

Participants

5

Reactant 3

HCID 962WaterHCID 147529954-(Bromomethyl)-3-methoxybenzonitrileHCID 24194345Phthalimide potassium salt

Product 1

HCID 22476088HCID 22476088, compoundYield 68.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

24.4 g (108 mol) of 4-bromomethyl-3-methoxybenzonitrile dissolved in 125 ml of DMF and 20.0 g of potassium phthalimide were stirred at RT for 24 h and then at 50° C. for 1 h. The mixture was poured into water, whereupon the product precipitated as solid. 21.5 g (68%) of the product were obtained.

Workup

  1. customprecipitated as solid

Sources & evidence

ORD record
ord-b3cc4f5af08f4e3899e5bffc6d891be8
Source dataset
uspto-grants-2005_05
Patent number
US06900319B2

Reaction notes

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