Methylamine → 3-[4-(3-Fluoro-benzyloxy)-phenyl]-propynoic Acid Methylamide

HRID 2184356Notes

Reaction equation

HRID 2184356 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][C:15](O)=[O:16])=[CH:9][CH:8]=1.[CH3:21][NH2:22]>>[CH3:21][NH:22][C:15](=[O:16])[C:14]#[C:13][C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]2[CH:18]=[CH:19][CH:20]=[C:2]([F:1])[CH:3]=2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 692917433-{4-[(3-Fluorophenyl)methoxy]phenyl}prop-2-ynoic acid

Product 1

HCID 117785643-[4-(3-Fluoro-benzyloxy)-phenyl]-propynoic Acid MethylamideYield 45%

Procedure

The title compound is prepared in analogy to example 5 d), starting from [4-(3-fluoro-benzyloxy)-phenyl]-propynoic acid and aqueous methylamine. Colorless solid. Yield=45%. MS: m/e=284.1 (M++H).

Workup

  1. customis prepared in analogy to example 5 d

Sources & evidence

ORD record
ord-fc015680870b44a9a3323d3b0a77f8cb
Source dataset
uspto-grants-2005_05
Patent number
US06900354B2

Reaction notes

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