Diethanolamine → 10-(Methoxycarbonyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid bis-(2-hydroxy-ethyl)-amide
Reaction equation
[CH3:1][O:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][N:8]2[C:16]([C:19]([OH:21])=O)=[CH:17][CH:18]=[C:7]2[CH2:6]1)=[O:4].[NH:22]([CH2:26][CH2:27][OH:28])[CH2:23][CH2:24][OH:25]>>[OH:25][CH2:24][CH2:23][N:22]([CH2:26][CH2:27][OH:28])[C:19]([C:16]1[N:8]2[C:7]([CH2:6][N:5]([C:3]([O:2][CH3:1])=[O:4])[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[CH2:9]2)=[CH:18][CH:17]=1)=[O:21]Participants
3
Procedure
The title compound was prepared by coupling the 10-(methoxycarbonyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid of step A with diethanolamine (1.2 equiv.), in the manner of Example 1, Step G,
Sources & evidence
- ORD record
- ord-2ed68591c72c40b58b7064e1deee5eba
- Source dataset
- uspto-grants-2005_05
- Patent number
- US06900200B2
Reaction notes
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