Ethyl Acrylate → Ethyl 4-oxo-4-(pyridin-3-yl)butanoate

HRID 2184724Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[O:8])[CH:2]=1.[C:9]([O:13][CH2:14][CH3:15])(=[O:12])[CH:10]=[CH2:11]>>[O:8]=[C:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[CH2:11][CH2:10][C:9]([O:13][CH2:14][CH3:15])=[O:12]

Participants

Reactant 2

HCID 8821Ethyl Acrylate

HCID 103713-Pyridinecarboxaldehyde

Product 1

HCID 4248889Ethyl 4-oxo-4-(pyridin-3-yl)butanoate

Procedure

The title compound was prepared from 3-pyridinecarboxaldehyde (20 g) and ethyl acrylate (22.4 g) as described in Example 1 to yield 5.1 g, ESMS (M+1)+208.

Workup

customto yield 5.1 g, ESMS (M+1)+208

Sources & evidence

ORD record: ord-a29fe2c7c53441fc840c2c5a22f593f5
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06399606B1

Reaction notes

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