反应详情

温度

0 °C

The t-butyl 1,5-di-[(4-methoxyphenyl)sulfonyl]-diazepine-2-carboxylate (0.45 g, 0.8 mmol) is dissolved in chloride (1.5 mL) and cooled down in an ice bath. Trifluoroacetic acid (1.5 mL, 19.0 mmol is added and the resulting solution is stirred at 0° C. for 3 hours. The reaction mixture is warmed to room temperature and an additional 1 mL of trifluroacetic acid is added. The resulting solution is stirred for an additional hour and the mixture is concentrated under reduced pressure. The residue is carried forward without further purification. MS (ESI): 485 (M+H+), 502 (M+NH4+).

1. temperaturecooled down in an ice bath
2. temperatureThe reaction mixture is warmed to room temperature
3. stirringThe resulting solution is stirred for an additional hour
4. concentrationthe mixture is concentrated under reduced pressure
5. customThe residue is carried forward without further purification