反应详情

4-(Ethoxycarbonyl)phenylzinc iodide in tetrahydrofuran (0.5M, 2 mL, 1 mmol) was added to a solution of 2-bromopyridine (0.16 g, 1 mmol) and tetrakis(triphenylphosphine)palladium(0) (63 mg, 0.05 mmol) in tetrahydrofuran (5 mL) and stirred at RT for 3 h. The reaction was quenched with saturated ammonium chloride and extracted three times with ethyl acetate. The combined organic phase was dried (MgSO4), concentrated in vacuo, and the residue chromatographed (silica gel, 10% ethyl acetate/hexane) to give the title compound as a yellow solid (0.15 g).

1. customThe reaction was quenched with saturated ammonium chloride
2. extractionextracted three times with ethyl acetate
3. dry with materialThe combined organic phase was dried (MgSO4)
4. concentrationconcentrated in vacuo
5. customthe residue chromatographed (silica gel, 10% ethyl acetate/hexane)