Methylamine → HCID 178482497, compound

HRID 2185102Notes

Reaction equation

HRID 2185102 reaction equation
[Cl:1][N:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[O:20][CH:19]=[N:18][CH:17]=3)=[C:12]([O:21][CH3:22])[CH:11]=2)[NH:3]1.[CH3:23][NH2:24].C1COCC1>C(COC)OC>[Cl:1][N:2]1[N:7]=[C:6]([NH:24][CH3:23])[CH:5]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[O:20][CH:19]=[N:18][CH:17]=3)=[C:12]([O:21][CH3:22])[CH:11]=2)[NH:3]1

Participants

5

Reactant 3

HCID 6329MethylamineHCID 8028TetrahydrofuranHCID 178493053HCID 178493053, compound

Product 1

HCID 178482497HCID 178482497, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

2,4-Dichloro-6-(4-oxazol-5-yl-3-methoxyphenylamino)triazine 214A (1.8 g, 5.4 mmol) was suspended in dimethoxyethane (50 mL). 2 M Methylamine in THF (27 mL, 54 mmol) was added dropwise and the reaction mixture stirred for 3 h. The crude product was filtered and triturated with ethanol (20 mL) and dried to yield 1.37 g (77%) of the title compound. LCMS Condition A retention time=2.61 min (>95%), M+H+=333.16 (100%).

Workup

  1. filtrationThe crude product was filtered
  2. customtriturated with ethanol (20 mL)
  3. customdried

Sources & evidence

ORD record
ord-6f1a1662584b4be3a07a0694c42fc3c5
Source dataset
uspto-grants-2002_06
Patent number
US06399773B1

Reaction notes

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