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HRID2185498

反应详情

EQUATION

反应方程式

HRID 2185498 的结构方程式

REACTANTS

反应物

8
结构：CI
HCID6328

Methyl iodide

CH3I

结构：Nc1cnc2ccccc2c1
HCID11375

3-Aminoquinoline

C9H8N2

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CC(C)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O
HCID637604

tert-Butoxycarbonyl-D-leucine

C11H21NO4

结构：CC(C)C[C@H](C(=O)O)N(C)C(=O)OC(C)(C)C
HCID6992561

未命名化合物

结构：CC(C)(C)OC(=O)NCC(=O)N[C@@H]1C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C1
HCID21341559

未命名化合物

结构：CCc1ccc2ncc(N)cc2c1
HCID22458751

未命名化合物

结构：CC(C)(C)OC(=O)NC[C@H]1C[C@H](C(=O)O)N(C(=O)OC(C)(C)C)C1
HCID53725027

未命名化合物

PRODUCTS

生成物

1
结构：CCc1ccc2ncc(NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]3C[C@H](CN)CN3)cc2c1
HCID70175963

未命名化合物

PROCEDURE

实验过程

This compound was prepared as for Compound M15, replacing N-tert-butoxycarbonyl-D-homophenylalanine with N-tert-butoxycarbonyl-N-methyl-D-leucine (made by treantment of N-tert-butoxycarbonyl-D-leucine with excess sodium hydride and methyl iodide in 1TF), trans-4-(N-tert-butoxycarbonylglycyl)amino-N-tert-butoxycarbonyl-L-proline with trans-4-(N-tert-butoxycarbonylaminomethyl)-N-tert-butoxycarbonyl-D-proline and coupling with 3-amino-6-ethylquinoline inst of 3-aminoquinoline.

WORKUP

后处理

  1. customThis compound was prepared as for Compound M15