Trifluoroacetic acid → HCID 22458282, compound

HRID 2185561Notes

Reaction equation

HRID 2185561 reaction equation
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C(OC([N:15]1[CH2:20][CH2:19][CH:18]([CH2:21][CH2:22][C:23](=[O:30])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>C(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[O:30]=[C:23]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH2:22][CH2:21][CH:18]1[CH2:17][CH2:16][NH:15][CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22458239HCID 22458239, compound

Product 1

HCID 22458282HCID 22458282, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (1.0 mL) was added to a solution of 1-(tert-butoxycarbonyl)-4-(3-oxo-3-phenylpropyl)piperidine (50 mg, 0.16 mmol, from Step C) in CH2Cl2 (1.0 mL) at rt. After stirring for 3 h, the solution was concentrated at reduced pressure. Toluene was added and evaporated at reduced pressure, and this was repeated with two additional portions of toluene. Drying under vacuum yielded the title compound as colorless crystals.

Workup

  1. concentrationthe solution was concentrated at reduced pressure
  2. additionToluene was added
  3. customevaporated at reduced pressure
  4. customDrying under vacuum

Sources & evidence

ORD record
ord-852a3e7b2f5745bd88cc6883ecc676e0
Source dataset
uspto-grants-2002_06
Patent number
US06399619B1

Reaction notes

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