2-Pyridinemethanamine → HCID 22452170, compound

HRID 2185810Notes

Reaction equation

HRID 2185810 reaction equation
C([O:3][C:4]([CH2:6][N:7]1[C:12](=[O:13])[C:11]([C:14](=[O:17])[NH:15][CH3:16])=[CH:10][C:9]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[N:8]1)=O)C.[NH2:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1>C1(C)C(C)=CC=CC=1>[CH3:25][O:24][C:21]1[CH:20]=[CH:19][C:18]([C:9]2[CH:10]=[C:11]([C:14](=[O:17])[NH:15][CH3:16])[C:12](=[O:13])[N:7]([CH2:6][C:4](=[O:3])[NH:26][CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=3)[N:8]=2)=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 195092-PyridinemethanamineHCID 22452283HCID 22452283, compound

Product 1

HCID 22452170HCID 22452170, compoundYield 44.5%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In xylene, 2-ethoxycarbonylmethyl-6-(4-methoxyphenyl)-4-methylcarbamoyl-2H-pyridazin-3-one and 2-(aminomethyl)pyridine were refluxed at 150° C. for 7 hours. Post-treatments were conducted as in Example 47-(2), whereby the title compound was obtained in a yield of 44.5%.

Sources & evidence

ORD record
ord-2aaf15aae15541928d8bec0b7ad257de
Source dataset
uspto-grants-2002_06
Patent number
US06403586B1

Reaction notes

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