2-Pyridinemethanamine → HCID 22452216, compound

HRID 2185812Notes

Reaction equation

HRID 2185812 reaction equation
[CH:1]1([CH2:4][N:5]2[C:10](=[O:11])[C:9]([C:12]([O:14]CC)=O)=[CH:8][C:7]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)=[N:6]2)[CH2:3][CH2:2]1.[NH2:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1>C1(C)C(C)=CC=CC=1>[CH:1]1([CH2:4][N:5]2[C:10](=[O:11])[C:9]([C:12](=[O:14])[NH:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)=[CH:8][C:7]([C:17]3[CH:18]=[CH:19][C:20]([O:23][CH3:24])=[CH:21][CH:22]=3)=[N:6]2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 195092-PyridinemethanamineHCID 22452200HCID 22452200, compound

Product 1

HCID 22452216HCID 22452216, compoundYield 84.2%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In xylene, 2-cyclopropylmethyl-4-ethoxycarbonyl-6-(4-methoxyphenyl)-2H-pyridazin-3-one and 2-(aminomethyl)pyridine were reacted at 140° C. for 1 hour. Post-treatments were conducted as in Example 58-(3), whereby the title compound was obtained in a yield of 84.2%.

Sources & evidence

ORD record
ord-ba6df2107d704ec8ba30fcef0457d96f
Source dataset
uspto-grants-2002_06
Patent number
US06403586B1

Reaction notes

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