Benzylamine → 4-Benzylcarbamoyl-2-cyclopentylmethyl-6-(4-methoxyphenyl)-2H-pyridazin-3-one

HRID 2185815Notes

Reaction equation

HRID 2185815 reaction equation
[CH:1]1([CH2:6][N:7]2[C:12](=[O:13])[C:11]([C:14]([O:16]CC)=O)=[CH:10][C:9]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[N:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:27]([NH2:34])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>C1(C)C(C)=CC=CC=1>[CH2:27]([NH:34][C:14]([C:11]1[C:12](=[O:13])[N:7]([CH2:6][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[N:8]=[C:9]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)[CH:10]=1)=[O:16])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 22452171HCID 22452171, compound

Product 1

HCID 224522964-Benzylcarbamoyl-2-cyclopentylmethyl-6-(4-methoxyphenyl)-2H-pyridazin-3-oneYield 78.5%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In xylene, 2-cyclopentylmethyl-4-ethoxycarbonyl-6-(4-methoxyphenyl)-2H-pyridazin-3-one and benzylamine were reacted at 140° C. for 2 hours. Post-treatments were conducted as in Example 68, whereby the title compound was obtained in a yield of 78.5%.

Sources & evidence

ORD record
ord-53bdea1f92ef495b9fae36490d22d3e6
Source dataset
uspto-grants-2002_06
Patent number
US06403586B1

Reaction notes

Loading…