Oxalyl chloride → HCID 22452646, compound

HRID 2185883Notes

Reaction equation

HRID 2185883 reaction equation
[C:1]([C:3]1[C:4]([O:16][CH3:17])=[C:5]([C:13](O)=[O:14])[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=2[CH:12]=1)#[N:2].C(Cl)(=O)C([Cl:21])=O>C(Cl)Cl>[C:1]([C:3]1[C:4]([O:16][CH3:17])=[C:5]([C:13]([Cl:21])=[O:14])[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=2[CH:12]=1)#[N:2]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 22452685HCID 22452685, compound

Product 1

HCID 22452646HCID 22452646, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A stirred mixture of 3-cyano-2-methoxy-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid (0.110 g, 0.476 mmol) and dry CH2Cl2 (2 mL) was treated with oxalyl chloride (51.9 μl) and dry N,N-dimethylformanide (˜5 μL) at ambient temperature. After 2.0 h, the solvent was evaporated in vacuo. The residue was dissolved in dry CH2Cl2 and used without further purification.

Workup

  1. customdry N,N-dimethylformanide (˜5 μL) at ambient temperature
  2. customthe solvent was evaporated in vacuo
  3. dissolutionThe residue was dissolved in dry CH2Cl2
  4. customused without further purification

Sources & evidence

ORD record
ord-2a5e11cac70d45029db67aef14b6663c
Source dataset
uspto-grants-2002_06
Patent number
US06403601B1

Reaction notes

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