Oxalyl chloride → HCID 22452672, compound

HRID 2185892Notes

Reaction equation

HRID 2185892 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]([OH:15])=O)[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=2[CH:12]=1.C(Cl)(=O)C([Cl:19])=O>C(Cl)Cl.CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]([Cl:19])=[O:15])[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=2[CH:12]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 22452645HCID 22452645, compound

Product 1

HCID 22452672HCID 22452672, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-methoxy-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid (0.20 g, 0.97 mmol) in DCM (5 mL) was added oxalyl chloride (0.11 mL, 1.21 mmol) and 1 drop of DMF. The mixture was stirred at room temperature for 2 h. The solvent was removed in vacuo and 3-methoxy-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride was used without purification.

Workup

  1. customThe solvent was removed in vacuo and 3-methoxy-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride
  2. customwas used without purification

Sources & evidence

ORD record
ord-de0db4e5718c4fb7b41a5a6b641bc610
Source dataset
uspto-grants-2002_06
Patent number
US06403601B1

Reaction notes

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