Oxalyl chloride → HCID 22452678, compound

HRID 2185902Notes

Reaction equation

HRID 2185902 reaction equation
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[C:4]=1[C:15]([OH:17])=O.C(Cl)(=O)C([Cl:21])=O>C(Cl)Cl.CN(C=O)C>[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[C:4]=1[C:15]([Cl:21])=[O:17]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 22452630HCID 22452630, compound

Product 1

HCID 22452678HCID 22452678, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 2,3-dimethoxy-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid (0.20 g, 0.85 mmol) in DCM (5 mL) was added oxalyl chloride (0.09 mL, 1.06 mmol) and 1 drop of DMF. The mixture was stirred at room temperature for 2 h. The solvent was removed in vacuo and the 2,3-dimethoxy-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride was used without purification.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe 2,3-dimethoxy-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride was used without purification

Sources & evidence

ORD record
ord-959021bbd3e748fe8653ae6fa58c77a0
Source dataset
uspto-grants-2002_06
Patent number
US06403601B1

Reaction notes

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