Piperidine → 7-Bromo-4-methoxy-2-(piperidin-1-yl)-benzooxazole

HRID 2186447Notes

Reaction equation

HRID 2186447 reaction equation
[Br:1][C:2]1[C:10]2[O:9][C:8](SC)=[N:7][C:6]=2[C:5]([O:13][CH3:14])=[CH:4][CH:3]=1.[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[Br:1][C:2]1[C:10]2[O:9][C:8]([N:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)=[N:7][C:6]=2[C:5]([O:13][CH3:14])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 224566517-Bromo-4-methoxy-2-methylsulfanylbenzooxazole

Product 1

HCID 224566607-Bromo-4-methoxy-2-(piperidin-1-yl)-benzooxazole

Procedure

Starting from 7-bromo-4-methoxy-2-methylsulfanylbenzooxazole (10.0 g) and piperidine (3.8 ml). Purification by chromatography on silica eluting with 30-100% ethyl acetate in hexane afforded the title compound as an off-white solid (10.7 g).

Workup

  1. customPurification by chromatography on silica eluting with 30-100% ethyl acetate in hexane

Sources & evidence

ORD record
ord-4131b1fea08641af91a9ebe9526d070e
Source dataset
uspto-grants-2002_06
Patent number
US06403791B1

Reaction notes

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