Diisopropylethylamine → HCID 9911085, compound

HRID 2186664Notes

Reaction equation

HRID 2186664 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@H:11]1[C@H:15]([OH:16])[C@H:14]([OH:17])[C@@H:13]([CH2:18][O:19][C:20]([F:23])([F:22])[F:21])[O:12]1.[N:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][NH2:32])=[CH:26][CH:25]=1.C(N(C(C)C)CC)(C)C>C(O)(C)C>[N:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][NH:32][C:2]2[C:3]3[N:4]=[CH:5][N:6]([C:7]=3[N:8]=[CH:9][N:10]=2)[C@@H:11]2[O:12][C@H:13]([CH2:18][O:19][C:20]([F:23])([F:22])[F:21])[C@@H:14]([OH:17])[C@H:15]2[OH:16])=[CH:26][CH:25]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 832754-PyridineethanamineHCID 56617573HCID 56617573, compound

Product 1

HCID 9911085HCID 9911085, compoundYield 30.7%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

(2R,3R,4S,5R)-2-(6-Chloro-purin-9-yl)-5-trifluoromethoxymethyl-tetrahydro-furan-3,4-diol (42 mg), 2-pyridin-4-yl-ethylamine (58 mg), and diisopropylethylamine (0.124 ml) were heated at 80° C. in isopropanol (5 ml) in a reactivial for 17 h. The solution was evaporated under a stream of nitrogen and purified by autoprep HPLC to afford the title compound as a colourless solid (16 mg).

Workup

  1. customThe solution was evaporated under a stream of nitrogen
  2. custompurified by autoprep HPLC

Sources & evidence

ORD record
ord-b007e5915e2f400da4afe38913d0403e
Source dataset
uspto-grants-2002_06
Patent number
US06407076B1

Reaction notes

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