反应详情

To a solution of 100 mg (0.23 mmol) 2-benzyl-N-(3,5-bis-trifluoromethyl-benzyl)-benzamide in 1 ml N,N-dimethylformamide at 0° C. were added 50 mg (0.25 mmol) potassium hexamethyldisilazide. Stirring was continued for 1 h at this temperature and 0.016 ml (0.25 mmol) methyl iodide were added. After stirring for 3 h at room temperature, ethyl acetate was added. The mixture was washed with brine, dried (magnesium sulfate) and evaporated. The solvent was removed in vacuo and the residue was purified by flash chromatography to give 90 mg (87%) of the title compound as a colourless oil.

1. additionwere added
2. stirringAfter stirring for 3 h at room temperature
3. washThe mixture was washed with brine
4. dry with materialdried (magnesium sulfate)
5. customevaporated
6. customThe solvent was removed in vacuo
7. customthe residue was purified by flash chromatography