反应详情

A solution of 130 mg (0.468 mmol) 6-chloro-4-phenoxy-nicotinic acid ethyl ester, 0.040 ml (0.47 mmol) morpholine and 0.065 ml (0.47 mmol) triethylamine in 7 ml tetrahydrofuran was stirred at reflux for 40 h. After cooling to room temperature the reaction mixture was filtered, diluted with ethyl acetate and washed with water and saturated aqueous sodium chloride solution. The organic layer was dried with sodium sulfate and concentrated. Flash column chromatography afforded 66 mg (43%) of the title compound as a white solid.

1. temperatureat reflux for 40 h
2. filtrationwas filtered
3. additiondiluted with ethyl acetate
4. washwashed with water and saturated aqueous sodium chloride solution
5. dry with materialThe organic layer was dried with sodium sulfate
6. concentrationconcentrated