Hydrochloric Acid → HCID 131723309, compound

HRID 2187033Notes

Reaction equation

HRID 2187033 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C:10]1[CH:18]=[CH:17][C:13]([N+:14]([O-:16])=[O:15])=[CH:12][CH:11]=1)=[O:8])[CH2:3][CH2:4][CH2:5][CH3:6].[ClH:26]>O1CCOCC1>[NH2:1][C@H:2]([C:7]([NH:9][C:10]1[CH:11]=[CH:12][C:13]([N+:14]([O-:16])=[O:15])=[CH:17][CH:18]=1)=[O:8])[CH2:3][CH2:4][CH2:5][CH3:6].[ClH:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131723310HCID 131723310, compound

Product 1

HCID 131723309HCID 131723309, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

BocNle-pNA (prepared in 1 (1); 2.96 g) was dissolved into a solution of 4N—HCl in dioxane (30 ml). After stirring the obtained solution for 1 hour at room temperature, dioxane was distilled off under reduced pressure and then by adding toluene (30 ml). The reaction mixture was crystallized in ether to give Nle-pNA.HCl (2.08 g).

Workup

  1. distillationdioxane was distilled off under reduced pressure
  2. additionby adding toluene (30 ml)
  3. customThe reaction mixture was crystallized in ether

Sources & evidence

ORD record
ord-3d5079848f3a40a4ae33afc4d03bff0b
Source dataset
uspto-grants-2002_06
Patent number
US06407206B1

Reaction notes

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